Prophet Muhammad (S.A.W.) was born and lived in Makkah for the first 52 years of his life. From 570 to 622 A.D.
Despite living in Makkah for 52 years he married a woman,who was a wealthy 40-year-old widow, named Khadija (R.A.) at the age of 25.
When he was 40, he began to receive revelations by the Angel Jibreal. Some of his peers respected his words and became his followers.
Many others, including tribal leaders,eventually were rude to his clan, Muhammad and his followers were harassed, and tortured.